Direct association of connexin36 with zonula occludens-2 and zonula occludens-3
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چکیده
منابع مشابه
The Structure of the Zonula Occludens
Replicas of freeze-fractured toad urinary bladder and gallbladder were analysed in an attempt to determine the fracturing properties and structure of the zonula occludens (tight junction). Chalcroft and Bullivant have proposed that the junction has a double set of fibrils with one set associated with each of the adjacent cell membranes. However, the fracturing pattern that is observed might als...
متن کاملSsociation of Connexin36 and Zonula Occludens-1 Ith Zonula Occludens-2 and the Transcription Factor Onula Occludens-1-associated Nucleic Acid-binding Rotein at Neuronal Gap Junctions in Rodent Retina
bstract—Most gap junctions between neurons in mammaian retina contain abundant connexin36, often in association ith the scaffolding protein zonula occludens-1. We now nvestigate co-association of connexin36, zonula occludens-1, onula occludens-2 and Y-box transcription factor 3 (zonula ccludens-1-associated nucleic acid-binding protein) in ouse and rat retina. By immunoblotting, zonula occluden...
متن کاملThe Dual Role of Zonula Occludens (ZO) Proteins
ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In addition, they provide a link between the integral membrane proteins and the filamentous cytoskeleton. ZO proteins belong to the large family of membrane-associated guanylate kinase (MAGUK)-like proteins compr...
متن کاملZonula occludens toxins and their prophages in Campylobacter species
BACKGROUND We previously showed that zonula occludens toxin (Zot) encoded by Campylobacter concisus zot (808T) gene has the potential to initiate inflammatory bowel disease. This Zot protein caused prolonged intestinal epithelial barrier damage, induced intestinal epithelial and macrophage production of tumor necrosis factor-α and enhanced the responses of macrophages to other microbes. In orde...
متن کاملZonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia
The structure and function of both adherens (AJ) and tight (TJ) junctions are dependent on the cortical actin cytoskeleton. The zonula occludens (ZO)-1 and -2 proteins have context-dependent interactions with both junction types and bind directly to F-actin and other cytoskeletal proteins, suggesting ZO-1 and -2 might regulate cytoskeletal activity at cell junctions. To address this hypothesis,...
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ژورنال
عنوان ژورنال: Neurochemistry International
سال: 2009
ISSN: 0197-0186
DOI: 10.1016/j.neuint.2009.01.003